The role of Lhx2 in hair follicle morphogenesis and regeneration
نویسنده
چکیده
5 Paper in this licentiate thesis 7 Abbreviations 8 Introduction 9 The hair follicle 9 Hair follicle morphogenesis 10 Molecular regulation of the HF morphogenesis 12 The hair cycle 13 Catagen 14 Telogen 15 Anagen 15 LIM-homeodomain transcription factors 18 Lhx2 19 Aim 21 Results and discussion 22 Expression of Lhx2 during HF morphogenesis and postnatal cycling 22 Transgenic over-expression of Lhx2 in HFs results in anagen induction 23 Mice with inactivated Lhx2 are unable to regenerate a normal hair shaft 28 Significantly reduced levels of Lhx2 during morphogenesis 30 Lhx2 and the HF stem cells 32 How does Lhx2 function in the HFs? 35 Final conclusions 36 Enkel svensk sammanfattning 38 Acknowledgements 40 References 41 Paper I
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Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.
The Lhx2 transcription factor plays essential roles in morphogenesis and patterning of ectodermal derivatives as well as in controlling stem cell activity. Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2(+) cells reside in the stem cell-enriched epithelial compartments (bulge, secondary hair germ) and c...
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